Protein Details: 5-hydroxytryptamine receptor 3D

Protein ID

ICDB_Pro_1135

Protein Name

5-hydroxytryptamine receptor 3D

Gene Name

HTR3D

Organism

Homo sapiens (Human)

Length

454 amino acids

AlphaFoldDB

AF-Q70Z44-F1-model_v4.pdb

Function

Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes;which when activated cause fast;depolarizing responses in neurons.

Sequence

MQKHSPGPPALALLSQSLLTTGNGDTLIINCPGFGQHRVDPAAFQAVFDRKAIGPVTNYSVATHVNISFTLSAIWNCYSRIHTFNCHHARPWHNQFVQWNPDECGGIKKSGMATENLWLSDVFIEESVDQTPAGLMASMSIVKATSNTISQCGWSASANWTPSISPSMDRARAWRRMSRSFQIHHRTSFRTRREWVLLGIQKRTIKVTVATNQYEQAIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVAPLALMQTPLPAGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Currarino Syndrome and Nephronophthisis 1

Location

Expressed in liver;as well as fetal and adult colon and kidney

DOI ID

10.1016/s0378-1119(03)00503-1; 10.1124/mol.106.032144; 10.1038/nature04728; 10.1101/gr.2596504

RefSeq

NP_001138615.1 [Q70Z44-4]; NP_001157118.1 [Q70Z44-1]; NP_872343.2; XP_016861343.1